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Best Practices: Buying Magic Mushrooms What is a CRO? – Contract Research Organizations

Centralized monitoring is the process of collecting data from multiple sources, such as multiple research sites or across patient populations, to a remote, central location that is located away from the sites. This data is then evaluated by teams that can include Contract Research Organization monitors, data managers, and statisticians.

Centralized monitoring has been used increasingly over the past decade as Contract Research Organization has been reshaped by increased data sets and the need for collaboration between sponsors and CROs regarding monitoring plans, and the use of new technologies to facilitate the same.

Centralized monitoring began with some potential benefits in mind. It allowed for all the source data to be collected in one electronic system that could be accessed and monitored remotely. While these benefits had been evident for some time, the real advantage was seen during the Pandemic, when travel bans and social distancing rules forced the need to implement centralized monitoring for many multi-center Contract Research Organization.

Centralized monitoring has proven to be a method of increasing efficiency and decreasing costs, while increasing the quality and validity of the research being performed. However, it cannot mitigate all the risks involved in multi-center research. Centralized monitoring, the tools used in its implementation, and the risk mitigation strategies employed have strengthened significantly over the past decade.

Despite the clear benefits involving increased efficiency and decreased costs, centralized monitoring requires critical thinking, prediction of potential risks and their key indicators, and upfront planning of strategies for the same.

However, through proper training, standardization and streamlining of processes, use of the appropriate software, predictive and advanced analytics, and collaborative and open communication between the central monitoring teams and on-site staff, coupled with onsite visits using adaptive monitoring, the benefits and risks can be ideally balanced.

With all that has been learned and modified in the central monitoring process, even in times of global emergencies these strategies can be used to successfully and efficiently run clinical trials across multiple sites.

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